Title of article
Saffron supplements modulate serum pro-oxidant-antioxidant balance in patients with metabolic syndrome: A randomized, placebo-controlled clinical trial
Author/Authors
-، - نويسنده Department of Anatomy and Cell biology, Birjand University of Medical Sciences, Birjand, Iran. Kermani, Tayyebeh , -، - نويسنده Pharmacological Research Center of Medicinal Plant, Faculty of Medicine, Mashhad University of Medical Science, Mashhad, Iran. Mousavi, Seyyed Hadi , -، - نويسنده Biochemistry of Nutrition Research Center, School of Medicine, Mashhad University of Medical Science, Mashhad, Iran. Shemshian, Maryam , -، - نويسنده Biochemistry of Nutrition Research Center, School of Medicine, Mashhad University of Medical Science, Mashhad, Iran. Norouzy, Abdolreza , -، - نويسنده Institute of Genetics and Developmental Biology, University of Chinese Academy of Sciences, Beijing, China. Mazidi, Mohsen , -، - نويسنده Biochemistry of Nutrition Research Center, School of Medicine, Mashhad University of Medical Science, Mashhad, Iran. Moezzi, Atefeh , -، - نويسنده Biochemistry of Nutrition Research Center, School of Medicine, Mashhad University of Medical Science, Mashhad, Iran. Moghiman, Toktam , -، - نويسنده Cardiovascular Research Center, Faculty of Medicine, Mashhad University of Medical Science, Mashhad, Iran. Ghayour-Mobarhan, Majid , -، - نويسنده Division of Medical Education, Brighton & Sussex Medical School, Rm 342, Mayfield House, University of Brighton, BN1 9PH, United Kingdom Ferns, Gordon. A.
Issue Information
فصلنامه با شماره پیاپی 0 سال 2015
Pages
7
From page
427
To page
433
Abstract
-
Abstract
Objectives: We have investigated the effect of a saffron supplement, given at a dose of 100 mg/kg, on prooxidant-antioxidant balance (PAB) in individuals with metabolic syndrome. Materials and Methods: A randomized, placebo-controlled trial design was used in 75 subjects with metabolic syndrome who were randomly allocated to one of two study groups: (1) the case group received 100mg/kg saffron and (2) the placebo control group received placebo for 12 weeks. The serum PAB assay was applied to all subjects before (week 0) and after (weeks 6 and 12) the intervention. Results: There was a significant (p=0.035) reduction in serum PAB between week 0 to week 6 and also from week 0 to week 12. Conclusion: Saffron supplements can modulate serum PAB in subjects with metabolic syndrome, implying an improvement in some aspects of oxidative stress or antioxidant protection.
Journal title
Avicenna Journal of Phytomedicine AJP)
Serial Year
2015
Journal title
Avicenna Journal of Phytomedicine AJP)
Record number
2324356
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