Interleukin-18 Antagonism Improved Histopathological Condi¬tions of Malaria Infection in Mice
JABBARZARE، Marzieh نويسنده Dept. of Human Anatomy, Faculty of Medicine & Health Sciences, Universiti Putra Malaysia, Selangor, Malaysia JABBARZARE, Marzieh , CHIN، Voon Kin نويسنده Dept. of Biomedical Sciences, Faculty of Medicine & Health Sciences, Universiti Putra Malaysia, Selangor, Malaysia CHIN, Voon Kin , TALIB، Herni نويسنده Dept. of Pathology, Faculty of Medicine & Health Sciences, Universiti Putra Malaysia, Selangor, Malaysia TALIB, Herni , YAM، Mun Fei نويسنده School of Pharmaceutical Sciences, Universiti Sains Malaysia, Penang, Malaysia YAM, Mun Fei , ADAM، Siti Khadijah نويسنده Dept. of Human Anatomy, Faculty of Medicine & Health Sciences, Universiti Putra Malaysia, Selangor, Malaysia ADAM, Siti Khadijah , HASSAN، Haniza نويسنده Dept. of Human Anatomy, Faculty of Medicine & Health Sciences, Universiti Putra Malaysia, Selangor, Malaysia HASSAN, Haniza , ABDUL MAJID، Roslaini نويسنده Dept. of Medical Microbiology and Parasitology, Faculty of Medicine & Health Sciences, Universiti Putra Malaysia,Selangor, Malaysia ABDUL MAJID, Roslaini , MAT TAIB، Che Norma نويسنده Dept. of Human Anatomy, Faculty of Medicine & Health Sciences, Universiti Putra Malaysia, Selangor, Malaysia MAT TAIB, Che Norma , MOHD MOKLAS، Mohamad Aris نويسنده Dept. of Human Anatomy, Faculty of Medicine & Health Sciences, Universiti Putra Malaysia, Selangor, Malaysia MOHD MOKLAS, Mohamad Aris , TAUFIK HIDAYAT، Mohamad نويسنده Dept. of Human Anatomy, Faculty of Medicine & Health Sciences, Universiti Putra Malaysia, Selangor, Malaysia TAUFIK HIDAYAT, Mohamad , Mohd Sidek، Hasidah نويسنده School of Bioscience and Biotechnology Study, Faculty of Science and Technology, University Kebangsaan Malaysia, Selangor, Malaysia , , BASIR، Rusliza نويسنده Dept. of Human Anatomy, Faculty of Medicine & Health Sciences, Universiti Putra Malaysia, Selangor, Malaysia BASIR, Rusliza
Background: Interleukin 18 (IL-18) exerts pleiotropic roles in many inflammatory-related diseases including parasitic infection. Previous studies have demonstrated the promising therapeutic potential of modulating IL-18 bioactivity in various pathological conditions. However, its involvement during malaria infection has yet to be established. In this study, we demonstrated the effect of modulating IL-18 on the histopathological conditions of malaria infected mice.
Methods: Plasmodium berghei ANKA infection in male ICR mice was used as a model for malaria infection. Modulation of IL-18 release was carried out by treatment of malarial mice with recombinant mouse IL-18 (rmIL-18) and recombinant mouse IL-18 Fc chimera (rmIL-18Fc) intravenously. Histopathological study and analysis were performed on major organs including brain, liver, spleen, lungs and kidney.
Results: Treatment with rmIL-18Fc resulted in significant improvements on the histopathological conditions of the organs in malaria-infected mice.
Conclusion: IL-18 is an important mediator of malaria pathogenesis and targeting IL-18 could prove beneficial in malaria-infected host.