Mn(III) complex catalyzed a green synthesis of 2-amino-4H-chromen-5(6H)-ones in basic aqueous solution at ambient temperature

An ecient and environmentally friendly method for the synthesis of 2- amino-chromen-5(6H)-ones as important pharmaceutical compounds has been developed using [N,N0-bis(benzoylacetone)-1,2-ethylenediimine]Mn(III) chloride (2.5 mol%) as a heterogeneous and inorganic catalyst. A mixture of an appropriate aldehyde, malononitrile and dimedone in the presence of a catalytic amount of Mn(III) complex resulted in excellent yields (95-100%) of the corresponding products at ambient temperature. This new methodology is of interest due to use of water as a green solvent, its short reaction time, high yields and no further purication.