Title of article
Fragile X Mental Retardation Protein is Reduced in Cerebella of Subjects with Autism
Author/Authors
Fatemi، Seyyed Hossein نويسنده Department of Psychiatry, Division of Neuroscience Research, University of Minnesota Medical School , , D Folsom، Timothy نويسنده Departments of Pharmacology and Neuroscience, University of Minnesota Medical School ,
Issue Information
فصلنامه با شماره پیاپی 0 سال 2010
Pages
2
From page
56
To page
57
Abstract
Autism and fragile X syndrome have multiple behavioral phenotypes in common, however there has been
little research into the potential role of fragile X mental retardation protein (FMRP) in autism. We sought to
measure protein levels of FMRP in the lateral cerebella of subjects with autism and matched controls. We found
significantly reduced levels of FMRP (p < 0.0063) in subjects with autism. The loss of FMRP expression in
subjects with autism may help explain behavioral deficits, presence of seizure, and reduction in GABA receptors
in subjects with autism.
Journal title
Iranian Journal of Psychiatry and Behavioral Sciences (IJPBS)
Serial Year
2010
Journal title
Iranian Journal of Psychiatry and Behavioral Sciences (IJPBS)
Record number
2384995
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