• Title of article

    MicroRNA Expression in B-Thalassemia and Sickle Cell Disease: A Role in The Induction of Fetal Hemoglobin

  • Author/Authors

    Saki، Najmaldin نويسنده Department of Hematology and Blood Banking School of Medical Sciences, Tarbiat Modares University, Tehran, Iran , , Abroun، Saeid نويسنده Hematology Department, School of Medical Sciences, Tarbiat Modares University, Tehran, Iran , , Soleimani، Masoud نويسنده , , Kavianpour، Maria نويسنده Health Research Institute, Research Center of Thalassemia and Hemoglobinopathy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran , , Shahjahani، Mohammad نويسنده Research Center of Thalassemia and Hemoglobinopathy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran , , Mohammadi Asl، Javad نويسنده , , Hajizamani، Saeideh نويسنده Health Research Institute, Research Center of Thalassemia and Hemoglobinopathy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran ,

  • Issue Information
    فصلنامه با شماره پیاپی 68 سال 2016
  • Pages
    10
  • From page
    583
  • To page
    592
  • Abstract
    Today the regulatory role of microRNAs (miRs) is well characterized in many diverse cellular processes. MiR-based regulation is categorized under epigenetic regulatory mechanisms. These small non-coding RNAs participate in producing and maturing erythrocytes, expressing hematopoietic factors and regulating expression of globin genes by post-transcriptional gene silencing. The changes in expression of miRs (miR-144/-320/-451/-503) in thalassemic/sickle cells compared with normal erythrocytes may cause clinical severity. According to the suppressive effects of certain miRs (miR-15a/-16-1/-23a/-26b/-27a/-451) on a number of transcription factors [myeloblastosis oncogene (MYB), B-cell lymphoma 11A (BCL11A), GATA1, Krüppel-like factor 3 (KLF3) and specificity protein 1 (Sp1)] during B globin gene expression, It has been possible to increasing ? globin gene expression and fetal hemoglobin (HbF) production. Therefore, this strategy can be used as a novel therapy in infusing HbF and improving clinical complications of patients with hemoglobinopathies.
  • Journal title
    Cell Journal (Yakhteh)
  • Serial Year
    2016
  • Journal title
    Cell Journal (Yakhteh)
  • Record number

    2385261

    • Link To Document
    https://search.isc.ac/dl/search/defaultta.aspx?DTC=10&DC=2385261