Attenuated Lead Induced Apoptosis in Rat Hepatocytes in the Presence of Lycopersicon Esculentum
Ahmadi Ashtiani، Hamidreza نويسنده Islamic Azad University, pharmaceutical sciences branch, Tehran, I.R. Iran. , , Khaki، Arash نويسنده , , Ejtemaei Mehr، Shahram نويسنده School of Medicine, Medical Sciences/University of Tehran, Tehran, Iran. , , Anjarani، Soghra نويسنده Reference Research Center Lab, Ministry of Health and Medical Education, Tehran, Iran. Anjarani, Soghra , Dadgarnejad، Manochehr نويسنده Cosmetic Products Research Center, Iran Food and Drug Adminstration, Ministry of Health and Medical Education, Tehran, Iran. Dadgarnejad, Manochehr , Alebouyeh، Mahmoud نويسنده Cosmetic Products Research Center, Iran Food and Drug Adminstration, Ministry of Health and Medical Education, Tehran, Iran. Alebouyeh, Mahmoud , Rastegar، Hossein نويسنده ,
Lead (Pb), has, for decades, being known for its adverse effects on various body organs and systems. In the present study, the damage of Pb on the Liver tissue apoptosis was investigated, and Lycopersicon esculentum as an antioxidants source was administered orally to prevent the adverse effects of Pb. Eighteen Wistar rats, randomized into three groups (n=6), were used for this study. Animals in Group A served as the control and were drinking distilled water. Animals in Groups B and C were drinking 1%Lead acetate (LA). Group C animals were, in addition to drinking LA, treated with 1.5 ml/day of Lycopersicon esculentum. Treatments were for three months. The obtained results showed that lead acetate caused significant reductions in the liver weight, plasma and tissue superoxide dismutase and catalase activity, but a significant increase in plasma and tissue malondialdehyde concentration but Lycopersicon esculentum have an inhibitory effect on LA liver adverse effect. So, it can be concluded that Lycopersicon esculentum have a significant protective effect on liver lead acetate adverse effects as well as, lead acetate -induced oxidative stress.