Anti-Mullerian Hormone as a Predictive Factor in Assisted Reproductive Technique of Polycystic Ovary Syndrome Patients
Aleyasin، Ashraf نويسنده MD, Professor of Gynecology and Obstetrics, Shariati Hospital, Tehran University of Medical Sciences , , Aghahoseini، Marzie نويسنده Department of Infertility, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran. Aghahoseini, Marzie , Mokhtar، Sara نويسنده Department of Infertility, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran. , , Fallahi، Parvin نويسنده Department of Infertility, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran. ,
This study aimed to assess the relationship between the serum levels of anti-mullerian hormone (AMH) and other hormonal markers and results of assisted reproductive techniques (ART) in polycystic ovary syndrome (PCOS) patients. This cohort study was conducted on 60 PCOS patients who were candidates for assisted reproductive techniques. In all patients the serum levels of AMH, follicle stimulating hormone (FSH) and luteinizing hormone (LH), estradiol (E2), free testosterone (fT), testosterone (T) and inhibin B were measured in the 3rd day of menstrual cycle. The relationship between serum level of measured hormonal markers with retrieved oocytes, mature oocytes, the number of transferred fetus and pregnancy rate were assessed. The cut-off value for the serum level of AMH and retrieved oocytes were determined. There was a significant direct correlation between the serum mullerian inhibiting substance (MIS) level with number of total picked up oocytes (r=0.412), mature oocytes (r=0.472) and embryo transfer (r=0.291). There was a linear and significant correlation between inhibin B and fertilization (r=0.283) Cut-off point for AMH level according to presence or absence of pregnancy was 4.8 ng/ml and it was not statistically significant (P=0.655). Area under curve (AUC) was 0.543. Cut-off point for MIS according to picked up oocytes was 2.7 ng/ml with area under the curve (ROC curve) of 0.724 (CI= 0.591-0.831) (P=0.002). Patients with PCOS who had AMH more than 2.7 ng/ml, the number of retrieved oocytes (6 or more) was higher than MIS/AMH