Sulfated Titania Nanoparticles: an Efficient Catalyst for the Synthesis of Polyhydroquinoline Derivatives through Hantzsch Multicomponent Reaction

در اين مقاله نانوذرات تيتاناي سولفاته با روش سل-ژل و تتراتيتانيوم ايزوپروپوكسيد به عنوان ماده اوليه سنتز شد. نانوذرات سنتز شده توسط پراش اشعه X، ميكروسكوپ الكتروني روبشي ، آناليز سطح ، اسپكتروسكوپي مادون قرمز و آناليز كيفي EDS شناسايي شد. نانوذرات سنتز شده به عنوان تركيب موثر ، قابل بازيابي و دوستدار محيط زيست براي سنتز مشتقات پلي هيدروكينولين توسط روش تك مرحله اي چندگانه با آلدهيدها، آمونيوم استات و 1،3 دي كربونيل تحت رفلاكس استفاده شد.

Sulfated titania nanoparticles (SO4 2- /TiO2 NPs) were synthesized using titanium tetraisopropoxide (TTIP) by the sol-gel method. The structure and morphology of the prepared nanocatalyst was characterized using X-ray diffraction (XRD), scanning electron microscopy (SEM) and Brunauer–Emmett–Teller (BET) methods as well as Fourier transform infrared (FT-IR) and energy dispersive X-ray (EDX) spectroscopy. The obtained nanoparticles were used as an efficient, reusable and environmentally friendly catalyst for the synthesis of polyhydroquinoline (PHQ) derivatives via a one-pot multicomponent reaction of various aldehydes, ammonium acetate and 1,3-dicarbonyl compounds under reflux conditions. The desired Hantzsch esters were obtained in good to excellent yields and short reaction times. The SO4 2- /TiO2 NPs could be recycled at least three times without significant loss of their catalytic activity.