Determination of the absolute redox potential of Methyldopa: experimental and simulation methods

The standard redox potential of Methyldopa, in aqueous solutions is calculated experimentally by cyclic voltammetry on the surface of the activated glassy carbon electrode and also obtained theoretically by using accurate ab initio calculations along with the available salvation model of a polarizable continuum model. Innovative application of both direct and indirect methods resulted in the theoretical standard electrode potential of the methyldopa in order of 0.68 and 0.74 mV, respectively. The experimental standard redox potential of Methyldopa was obtained to be 0.72 mV versus standard Hydrogen Electrode-which is in good agreement with theoretical values.