Electrochemical Determination of Amitriptyline using a Nanocomposite Carbon Paste Electrode in Human Body Fluids

A carbon nanocomposite electrode has been designed by incorporation of montmorillonite nanoclay into the carbon ionic liquid electrode for the electrochemical determination of amitriptiline . The surface of the proposed electrode was characterized by scanning electron microscopy. The presence of ionic liquid as a binder is believed to be responsible for the electrocatalytic activity of the proposed electrode for oxidation of amitriptyline. Low detection limit of 24 nM for amitriptyline was achieved. High stability and reproducibility as well as the ease of preparation, low cost and surface renewal made this electrode ideal for the determination of amitriptyline in human body fluids.