Identification and antifungal susceptibility pattern of Candida species isolated from patients with nosocomial candiduria

Introduction: Nosocomial candiduria could be due to cystitis, pyelonephritis, or fungus ball in the urinary tract system. Several reports have shown candidemia and upper urinary tract involvement as the complications of candiduria. The aim of this study was to assess nosocomial candiduria; identify Candida isolates and determine their drug susceptibility pattern. Materials and Methods: Urine samples of 115 hospitalized patients were collected during a period of five months. Candida species were isolated and identified using conventional and molecular (PCR-RFLP) diagnostic methods. Antifungal susceptibility profiles for amphotericin B and fluconazole were performed using broth microdilution method, based on the Clinical and Laboratory Standards Institute (CLSI) M27-A2 guideline. Results: Nosocomial candiduria was diagnosed in 5 (4.3%) patients. The isolated Candida species were identified as Candida albicans (n: 4) and C. glabrata (n: 2). Two strains of C. albicans, and C. glabrata were resistant to fluconazole. Conclusion: Similar to several reports, the results of this study show that C. albicans is the main Candida species causing nosocomial candiduria and drug resistant Candida species are causative agents of candiduria in hospitalized patients.