Title of article
Clinical Outcomes and Electrolyte Balance Factors in Complex Cardiac Operations in Adults; Del Nido® Versus Custodiol® Cardioplegia Solutions: A Randomized Controlled Clinical Trial
Author/Authors
Forouzan-Nia Seyed-Khalil نويسنده , Najafi Atabak نويسنده Associate Professor of Anesthesiology , Mahdavi Gorabi Armita نويسنده Department of microbiology, Tabriz University of medical sciences, Tabriz, Iran. , Mortazian Meysam نويسنده Department of Surgery, Faculty of Medicine, AJA University of Medical Sciences, Tehran, IR Iran , Ghiasi Abbas نويسنده Department of Anesthaesiology and Critical Care, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran. , Mehrabanian Mohammad Javad نويسنده Department of Anesthesiology, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran , Dehghani Firoozabadi Mehdi نويسنده Department of Anesthesiology, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran , Ahmadi Tafti Seyed Hossein نويسنده Department of Cardiothoracic Surgery, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran , Zeraatian Nejad Davani Sam نويسنده Cardiovascular Surgery Department, Rasool Akram Hospital, Iran University of Medical Sciences, Tehran, Iran , Soltaninia Hassan نويسنده Department of Cardiothoracic Surgery, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran , Gorjipour Farhad نويسنده Iranian Scientific Society of Extracorporeal Technology, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran
Pages
8
From page
1
To page
8
Abstract
[Background]Cardioplegia is used for protection of myocardium during cardiac operations. Del Nido® (DN) and Custodiol® cardioplegia (CC) solutions are used for prolonged protection of the myocardium during cardiopulmonary bypass (CPB). Custodiol® cardioplegia solution is gaining popularity for myocardial protection during cardiopulmonary bypass.[Objectives]This study aimed to compare the effects of Custodiol® with another cardioplegia solution, Del Nido®, on myocardial protection during cardiopulmonary bypass.[Methods]In a randomized controlled clinical trial, forty patients were randomly allocated to Del Nido® and Custodiol® (CC) groups. Patients in both groups received a standard anesthesia protocol. For cardioplegia, in the DN group, the Del Nido® solution was administered every 90 minutes by the antegrade route. In the CC, group, the Custodiol® solution was administered in the same way at the beginning of the cardioplegia. Demographic information, blood chemistry parameters and other related perioperative and postoperative clinical indices were recorded.[Results]Frequency of female patients was 14/21 (66.66%) in the DN and 12/19 (63.15%) in the CC group (P = 0.816), age was 57.14 ± 12.48 years versus 59.47 ± 11.96 years (P = 0.551), weight was 70.95 ± 9.56 kilograms versus 69.63 ± 7.64 kilograms (P = 0.635), CPB time was 103.19 ± 23.43 minutes versus 97.36 ± 16.7 minutes (P = 0.376), and cross-clamp time was 73.76 ± 19.66 minutes versus 83.95 ± 16.14 minutes (P = 0.083). Blood chemistry and blood gas analysis revealed a similar trend between the two groups in these parameters (P > 0.05) except for higher sodium levels after cardioplegia (P = 0.016) and end of CPB (P = 0.002), potassium levels after cardioplegia (P = 0.029), and bicarbonate anions at the end of bypass (P = 0.03) in the Custodiol® group.[Conclusions]In conclusion, CC and DN offer effective myocardial protection during cardiopulmonary bypass. It is recommended to restrict the use of CC in patients susceptible to electrolyte disturbances.
Journal title
Astroparticle Physics
Serial Year
2018
Record number
2412070
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