Title of article
In Vivo and In Vitro Studies on Neutralizing Effects of Acorus calamus and Withania somnifera root extracts against Echis carinatus venom
Author/Authors
MEENATCISUNDARAM, S. Department of Microbiology - Nehru Arts and Science College - Coimbatore, India , SINDHU, M. Department of Microbiology - Nehru Arts and Science College - Coimbatore, India
Pages
5
From page
26
To page
30
Abstract
Neutralization effects of Acorus calamus and Withania somnifera root extracts were tested against Echis carinatus venom. Both plant extracts were effectively neutralized the various pharmacological activities induced by Echis carinatus venom. About 0.14 mg of Acorus calamus and 0.16 mg of Withania somnifera root extracts were able to completely neutralize the lethal activity of 2LD50 of Echis carinatus venom. Various pharmacological activities like haemorrhagic, coagulant, edema and phospholipase activities were effectively neutralized by both plant extracts. The above observations confirmed that both plant extracts possess potent snake venom neutralizing compounds, which inhibit the activity of Echis carinatus venoms.
Keywords
Echis carinatus Venoms , Acorus calamus , Withania somnifera , Plant extracts , lethality , PLA2
Journal title
Astroparticle Physics
Serial Year
2011
Record number
2414040
Link To Document