Title of article
Synthesis and In-vitro Cytotoxicity Assessment of N-(5-(Benzylthio)-1,3,4- thiadiazol-2-yl)-2-(4-(trifluoromethyl)phenyl)acetamide with Potential Anticancer Activity
Author/Authors
Aliabadi, Alireza Department of Medicinal Chemistry - Faculty of Pharmacy - Kermanshah University of Medical Sciences , Hasanvand, Zaman Department of Medicinal Chemistry - Faculty of Pharmacy - Kermanshah University of Medical Sciences, Kermanshah - Student Research Committee - Kermanshah University of Medical Sciences , Kiani, Amir Department of Pharmacology - Toxicology and Medical Services - Faculty of Pharmacy - Kermanshah University of Medical Sciences , Mirabdali, Saber Student Research Committee - Kermanshah University of Medical Sciences, Kermanshah - Department of Pharmacology - Toxicology and Medical Services - Faculty of Pharmacy - Kermanshah University of Medical Sciences
Pages
7
From page
687
To page
693
Abstract
Cancer is the second leading cause of death in the world. Despite advances in the diagnosis and treatment, overall survival of patients still remains poor. Hence, there is an urgent need for development of new anticancer agents. Considering promising biological activity of 1,3,4-thiadiazole derivatives, in the present study, synthesis and cytotoxicity assessment of new derivatives of this ring was done. All synthesized compounds were characterized by NMR, IR and MS spectroscopic methods. Obtained data from MTT assay showed that all compounds 3a- 3l had better anticancer activity against MDA(breast cancer) compared to PC3(prostate cancer) and
U87(Glioblastoma). Compound 3 g with m-OCH3 moiety on the phenyl ring was the most potent one in this series with IC50 = 9 μM against MDA breast cell line in comparison with imatinib(IC50 = 20 μM) as reference drug.
Keywords
Synthesis , 1,3,4-Thiadiazole , MTT assay , Breast cancer
Journal title
Astroparticle Physics
Serial Year
2013
Record number
2415061
Link To Document