Title of article
Endoplasmic Reticulum Stress and Unfolded Protein Response Pathways: Potential for Treating Age-related Retinal Degeneration
Author/Authors
Haeri, Mohammad SUNY Eye Institute - Departments of Neuroscience and Physiology and Ophthalmology - SUNY Upstate Medical University, Syracuse, NY, USA , Knox, Barry E SUNY Eye Institute - Departments of Neuroscience and Physiology and Ophthalmology - SUNY Upstate Medical University, Syracuse, NY, USA
Pages
15
From page
45
To page
59
Abstract
Accumulation of misfolded proteins in the endoplasmic reticulum (ER) and their
aggregation impair normal cellular function and can be toxic, leading to cell death.
Prolonged expression of misfolded proteins triggers ER stress, which initiates a
cascade of reactions called the unfolded protein response (UPR). Protein misfolding
is the basis for a variety of disorders known as ER storage or conformational diseases.
There are an increasing number of eye disorders associated with misfolded proteins
and pathologic ER responses, including retinitis pigmentosa (RP). Herein we review
the basic cellular and molecular biology of UPR with focus on pathways that could
be potential targets for treating retinal degenerative diseases.
Keywords
ER Stress , Unfolded Protein Response , Age-related Retinal Degeneration , Misfolded Protein , Protein Aggregation , Retinal Degenerative Diseases
Journal title
Astroparticle Physics
Serial Year
2012
Record number
2416253
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