Title of article
Introduction of HER-2 and a Short Review on Its Role in Prognosis and Treatment of Breast Cancer
Author/Authors
Mirmalek, Abbas Department of Surgery - Islamic Azad University - Tehran Medical Sciences Branch, Tehran , Elhamkani, Fatemeh Tehran University of Medical Sciences and Health Services - Shariati Hospital, Tehran , Salimi Tabatabaee, Alireza Students’ Research Committee - Islamic Azad University - Tehran Medical Sciences Branch, Tehran , Mahmoodzadeh, Hossein Tehran University of Medical Sciences and Health Services - Shariati Hospital, Tehran , Parsa, Yekta Students’ Research Committee - Islamic Azad University - Tehran Medical Sciences Branch, Tehran , Yadollah-Damavandi, Soheila Students’ Research Committee - Islamic Azad University - Tehran Medical Sciences Branch, Tehran , Jangholi, Ehsan Young Researchers Club - Islamic Azad University - Tehran Medical Sciences Branch, Tehran
Pages
13
From page
132
To page
144
Abstract
Human Epidermal growth factor Receptor-2 (HER-2) as a new prognostic and predictive factor has been believed as an essential measurement in breast carcinoma. About 280 articles were reviewed and 115 were referred in this review article on HER-2. HER-2 is an oncoprotein epidermal growth factor receptor produced by a so-called cell surface oncogene. Overexpression results in aggressive behavior, early metastasis to lymph nodes and distant areas, and poor prognosis in breast cancer. HER-2 seems to be a prognostic and predictive factor and must be considered in all breast cancer cases.
Keywords
Breast Cancer , Human Epidermal growth factor Receptor-2 , Prognosis , HER-2 , Review
Journal title
Astroparticle Physics
Serial Year
2014
Record number
2417940
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