Title of article
Electrochemical Oxidation and Thermodynamic Parameters for an Anti-viral Drug Valacyclovir
Author/Authors
Devarushi, Umesh S Department of Chemistry - Karnatak University’sKaranatakScience College , Shetti, Nagaraj P Depatment of Chemistry - K.L.E. Institute of Technology , Tuwar, Suresh M Department of Chemistry - Karnatak University’sKaranatakScience College , Seetharamappa, J P. G. Department of Studies in Chemistry - Karnatak University
Pages
15
From page
102
To page
116
Abstract
The electro-oxidation of valacyclovir has been studied at a glassy carbon electrode in phosphate buffer media by using cyclic voltammetric technique. Effects of anodic peak potential (Epa), anodic peak current (ipa), pH and heterogeneous rate constant (ko) have been discussed, single irreversible voltammogram was observed. The effects of scan rate, pH, concentration and temperature were evaluated. The electrode processes were shown to be diffusion controlled and irreversible involving adsorption effects. The electro-oxidation product of valacyclovir has been identified by MALDI2-((2-amine-6,8-dioxo-7,8-dihydro-3H-purin9(6H)-yl)methoxy)ethyl2-amino-3-methylbutanoate), involving 2-electron and 2-porton oxidation. Thermodynamic parameters such as activation energy Ea=27.51 kJmol-1, enthalpy ΔH#=25.03 kJmol-1, entropy ΔS#=-284.8 JK-1mol-1, Gibbs free energy ΔG#=109.9 kJmol-1 and Arrhenius factor, logA=-2.08 and analytical parameters linearity range 5.0×10-3 to 7.5×10-5 M, LOD=1.44 μM, LOQ=4.83 μM and RSD=5.26% were calculated and presented.
Keywords
Valacyclovir , Voltammetric techniques , Electrochemical studies , Oxidation thermodynamic parameters
Journal title
Astroparticle Physics
Serial Year
2017
Record number
2418747
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