Quetiapine-Induced Enuresis: Two Case Reports

Quetiapine is an effective and well-tolerated atypical dibenzothiazepine antipsychotic with higher affinity for 5-hydroxytryptophan than D2 dopamine receptors. It is a generally well-tolerated drug, yet, is remotely associated with urinary incontinence. Urinary incontinence is an embarrassing and distressing side effect of antipsychotic drugs. This paper reports on 2 patients with bipolar disorder, who developed urinary incontinence after treatment with quetiapine, and suggests dose reduction as the proper method for addressing this side effect. Nocturnal enuresis should be enquired through direct yet sensitive questions. The inevitable corollary is that patients treated with quetiapine should be properly monitored for nocturnal enuresis. A proper response to this side effect does not necessarily cease the antipsychotic medication.