Correlation between HLA System and Primary Vesicoureteral Reflux

Objectives: The polygenic mode for inheritance of vesicoureteral reflux (VUR) is a debutable issue. Our study is aimed to investigate the correlation between HLA system and VUR. Materials: the study included thirty patients with VUR and sixty patients from kidney donors as control group. Initially the HLA formulas of each patient were detected to racial-geographical distribution as well as common and specific antigen. Then, Relative Risk (RR) for the class 1 antigens of the HLA system was calculated and the X2 statistical test was performed for the antigens with RR>1 to establish a significant association between HLA system and VUR. Results: Increased frequency of the genes HLA-A9 HLA-B44 were characterized by statistical analysis (RR>1, X2>3.84) therefore, the significant correlation was found between VUR and HLA system (P<0.05) Conclusion: There are significant correlation between VUR and HLA-A9 and HLA-B44. However, more study is necessary that these genes may become markers for VUR.