Title of article
Metformin; a mini-review to its antioxidative and anti-inflammatory properties
Author/Authors
Abbaszadeh, Abolfazl Department of Surgery - Lorestan University of Medical Sciences, Khorramabad , Koushki, Sahar Student Research Committee - Lorestan University of Medical Sciences, Khorramabad , Koushki, Shirin Student Research Committee - Lorestan University of Medical Sciences, Khorramabad , Eskandarzadeh, Marzieh Student Research Committee - Lorestan University of Medical Sciences, Khorramabad , Hasanvand, Amin 3Department of Pharmacology and Toxicology - Faculty of Pharmacy - Lorestan University of Medical Sciences, Khorramabad
Pages
4
From page
7
To page
10
Abstract
Metformin, a hypoglycemic drug, increases peripheral glucose uptake, decreases liver glucose production and suppresses insulin resistance in liver and skeletal muscle. The molecular anti-inflammatory mechanism of metformin involves the reduction of the level of pro-inflammatory cytokines through AMPK activation. It can reduce endothelial dysfunction by ameliorating the expression of inflammatory gene and protein like vascular cell adhesion molecule-1 (VCAM-1), and vasodilating maternal vessels. Many studies showed that AMPK activation were the main contributors to the antioxidant and anti-inflammatory effects of metformin.
Keywords
Metformin , Antioxidative , Anti-inflammatory
Journal title
Journal of Renal Injury Prevention
Serial Year
2018
Journal title
Journal of Renal Injury Prevention
Record number
2435191
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