Manganese (II) chloride tetrahydrate: An efficient and environmentally benign nature catalyst for the synthesis of substituted dihydro-2-oxypyrroles at ambient temperature

In this present paper, we have reported an efficient, simple and environmentally benign nature methodology for the synthesis of substituted dihydro-2-oxypyrrole via a one-pot four-component domino condensation of dialkyl acetylenedicarboxylate, formaldehyde and amines (aromatic and aliphatic) under ambient temperature with excellent yields and short reaction times. Manganese (II) chloride tetrahydrate (MnCl2.4H2O) has been used as a mild, economical and environmentally friendly catalyst for preparation of substituted dihydro-2-oxypyrrole. The environmentally benign nature, simple, inexpensive and non-toxic catalyst, easily separated with no column chromatographic separation, high catalytic activity, highly efficient is an option for the simple synthesis of these rings.