Title of article
A new procedure for preparation of polyethylene glycol-grafted magnetic iron oxide nanoparticles
Author/Authors
Khoee, Sepideh Polymer Chemistry Department - School of Science - University of Tehran, Tehran , Kavand, Alireza Polymer Chemistry Department - School of Science - University of Tehran, Tehran
Pages
6
From page
1
To page
6
Abstract
Magnetic iron oxide nanoparticles (MNPs) have
been widely explored for use in biomedical applications. In
the present study, iron oxide nanoparticles were connected
to methoxy poly(ethylene glycol) (mPEG) via a new
method. The mPEG was acrylated at first and Michael
reaction was carried out between acrylated mPEG and
3-aminopropyl triethoxysilane as a coupling agent. The
chemical structures of modified mPEG were characterized
by Fourier transform-infrared spectroscopy (FT-IR) and
nuclear magnetic resonance. In the next step, iron oxide
nanoparticle was coupled with the above-mentioned adduct.
Preparation of magnetic nanoparticles with average particle
size of 20–30 nm was proved by scanning electron
microscopy. The structure of mPEG grafted on the surface
of MNPs was confirmed by FT-IR spectroscopy and thermal
gravimetric analysis. The synthesized nanoparticles have
the potential to be used in different biomedical applications.
Keywords
Iron oxide nanoparticles , Polyethylene glycol , Surface modification , Sol–gel reaction
Journal title
Astroparticle Physics
Serial Year
2014
Record number
2435930
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