Electrosynthesis of nano‑sized pyran and chromene derivatives by one‑pot reaction between cyclic‑1,3‑diketons, malononitrile/ethyl cyanoacetate, and isatins

An efficient and sustainable method was developed for the electrocatalytic synthesis of nano-sized 4H-pyran derivatives via a green, one-pot, three-component condensations of cyclic-1,3-diketones [including 1H-indene-1,3(2H)-dione, cyclohexane- 1,3-dione, cyclopentane-1,3-dione, pyrimidine-2,4,6(1H,3H,5H)-trione], malononitrile or ethyl cyanoacetate, and isatins in an undivided electrochemically cell applying potassium bromide as the electrolyte in the alcoholic media. This electrosynthesis was introduced as a reliable and cost-effective approach for the high-yielding synthesis (76–92%) of the target compounds. The synthesized 4H-pyran and chromene nanoparticles could open an effective way for production of nano-sized drugs.