Title of article
Mercury Intoxication in Rats: Iron and Vitamin B6 as A Potential Therapy
Author/Authors
Taimur Islam, Mohammad Department of Pathobiology - Bangabandhu Sheikh Mujibur Rahman Agricultural University, Gazipur, Bangladesh , Golam Haider, Mohammad Department of Pathobiology - Bangabandhu Sheikh Mujibur Rahman Agricultural University, Gazipur, Bangladesh , Kumar Talukder, Anup Department of Gynecology - Obstetrics and Reproductive Health - Bangabandhu Sheikh Mujibur Rahman Agricultural University, Gazipur, Bangladesh , Talukder, Milton Department of Physiology and Pharmacology - Patuakhali Science and Technology University, Babugonj, Barisal, Bangladesh , Rohul Amin, Mohammad Department of Physiology and Pharmacology - Patuakhali Science and Technology University, Babugonj, Barisal, Bangladesh , Alam, Khondoker Jahengir Department of Pathology and Parasitology - Patuakhali Science and Technology University, Babugonj, Barisal, Bangladesh
Pages
8
From page
19
To page
26
Abstract
Background: Mercury in any form is poisonous and mercury toxicity most commonly affects the
nervous, gastrointestinal (GI) and urinary systems. The aim of this study was to investigate the
specific effect associated with mercury toxicity and to evaluate the effectiveness of iron and
vitamin B6 supplement on mercury-induced toxicities in rats.
Methods: This experiment was performed on 25 rats. All rats were randomly divided into five
equal groups (5×5). Toxic signs and body weight change, hematological parameters like total
erythrocyte count (TEC), total leukocyte count (TLC), hemoglobin content (Hb%) and packed cell
volume (PCV) and postmortem changes in rats were investigated.
Results: Rats treated with mercury intoxication showed severe toxic signs and significantly
(P<0.01) reduced TEC, TLC, Hb content and PCV. However, rats treated with mercury intoxication
in combination with iron and vitamin B6 showed physiological levels of hematological parameters.
Mercury intoxication induced the congestion and necrosis in lung, liver, heart and kidney, whereas
combined use of mercury intoxication, iron and vitamin B6 recovered the condition.
Conclusion: Combined use of iron and vitamin B6 is highly protective against mercury toxicity.
Keywords
Hematological Parameter , Iron , Mercury Intoxication , Vitamin B6
Journal title
Astroparticle Physics
Serial Year
2017
Record number
2441193
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