Correlation between Post-Percutaneous Coronary Intervention CKMB Elevation and One-Year Major Adverse Cardiac and Cerebrovascular Events

Background: CKMB elevation after percutaneous coronary intervention (PCI) correlates with major adverse cardiac and cerebrovascular events (MACCE). There is, however, some controversy over this issue, with some studies having reported different conclusions. We assessed the correlation between the CKMB level after PCI and one-year MACCE incidence in these patients. Methods: We measured the CKMB level before and after PCI in 221 patients with normal baseline CKMB who underwent PCI at Ekbatan University Hospital, Hamedan, Iran, between April 2013 and October 2013, and divided them into 4 groups based on the post-PCI CKMB level. Then, we evaluated one-year MACCE incidence. Results: CKMB elevation was detected in 81 (37.6%) patients and MACCE occurred in 11 (5%) patients. CKMB elevation after PCI was correlated to MACCE. The predictors of CKMB elevation were hyperlipidemia, number of deployed stents, stent diameter ≥4 mm, and complicated PCI. Conclusions: CKMB elevation after PCI was detected in 37.6% of the study population and was common in the setting of hyperlipidemia, more than 1 stent deployment, stent diameter ≥4 mm, and complicated PCI. MACCE at 1 year occurred in 5% of the patients and was correlated with the post-PCI CKMB level ≥3 times of normal, history of diabetes mellitus, history of hypertension, and inappropriate use of clopidogrel.