Meta-Analysis of Association Between BRIP1 Polymorphisms and Breast Cancer Risk

Context: Several studies have assessed the associations between BRCA1-interacting protein 1 (BRIP1) polymorphisms and risk of breast cancer. However, their results were mostly inconsistent and questionable. Objectives: The aim of the current study was to appraise the association between BRIP1 variants and susceptibility to breast cancer through performing a meta-analysis. Data Sources: We investigated and gathered English literature existed in Medline, PubMed, Embase, Web of Science, and Google Scholar (up to January 2018) by the search terms “BRIP1 gene”, “breast cancer”, “SNPs”, and “polymorphism”. Results: Case-control researches with almost identical strategies and adequate information for calculation of odds ratio (OR) with 95% confidence interval (CI) were included in the present study. Consequently, 3 publications in distinct ethnic groups including 986 cases and 1087 controls were chosen. The meta-analysis showed that the single-nucleotide polymorphism of rs4988344 in the BRIP1 gene was associated with breast cancer risk in homozygous (P = 0.46 for heterogeneity, or = 1.66, 95% CI = [1.05, 2.63]) and recessive models (P = 0.44, or = 1.62, 95% CI = [1.07, 2.46]), while rs7213430 was associated with breast cancer in dominant model (P = 0.03 for heterogeneity, or = 0.74, 95% CI = [0.55, 0.98]). Conclusions: The current meta-analysis showed the association between certain BRIP1 polymorphisms and breast cancer risk.