Title of article
Synthesis and Biological Evaluation of New 1, 4-Dihydropyridines as Antihypertensives Agents in Rats
Author/Authors
Jorjani, Masoumeh Department of Pharmacology, Faculty of Medicine, Shaheed Beheshti University of Medical Sciences, Tehran , Rastegar, Hossein Department of Pharmacology, Faculty of Medicine, Shaheed Beheshti University of Medical Sciences, Tehran , Roshanzamir, Farshad Department of Pharmacology, Faculty of Medicine, Shaheed Beheshti University of Medical Sciences, Tehran , Varmazyari, Mehdí Department of Toxicology and Pharmacology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran , Abdollahi, Mohammad Department of Toxicology and Pharmacology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran , Zarghi, Afshin Department of Pharmaceutical Chemistry, School of Pharmacy, Shaheed Beheshti University of Medical Sciences, Tehran
Pages
4
From page
43
To page
46
Abstract
New analogues of nifedipine, as a known calcium channel blocker, were synthesized by
replacing the orthonitrophenyl group on position 4 with 1-(4-Nitrobenzyl)-5-imidazolyl or 2-
methylthio-1-(4-Nitrobenzyl)-5-imidazolyl substituent. Effects of the new synthesized
compounds on blood pressure were studied at 15, 30 and 60 min after administration by indirect
tail-cuff method and compared with nifedipine in male rat.
The results indicate that all compounds reduce mean systolic blood pressure but their
effectiveness is less than nifedipine. The onset of action of compounds 6c ,6d ,6e and 6g is also
slower than the parent drug.
Keywords
1,4-Dihydropyridines , Antihypertensive Activity , Rat
Journal title
Astroparticle Physics
Serial Year
2003
Record number
2447336
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