A simple and green approach for the synthesis of substituted dihydro2oxypyrroles catalyzed by nanoFe3O4@SiO2/SnCl4 superparamagnetic nanoparticles

In this work, an efficient and green procedure for the synthesis of dihydro-2-oxypyrroles has been developed. One-pot fourcomponent condensation reaction of aniline derivatives (2 mmol), dialkyl acetylene dicarboxylate (1 mmol), and aldehydes ( 1 mmol) was done in ethanol at 65 °C in the presence of nano-Fe3O4@SiO2/SnCl4 as a magnetically reusable heterogeneous acid catalyst. The obtained dihydro-2-oxypyrroles were purified without any chromatography techniques. The structure of obtained pure products was identified by physical properties and spectroscopic data such as FT-IR, 1H NMR, 13C NMR and mass spectroscopy. This protocol consistently has the advantages of excellent yields, short reaction time, simple workup, recyclability of the catalyst up to six runs without appreciable loss of activity.