Simultaneous Electrochemical Determination of Paracetamol, Dopamine and Diclofenac at Diacerein Modified Carbon paste Electrode: A Voltammetric Study

Diacerein was used for the modification of carbon paste electrode (CPE) to determine the electrochemical behavior of paracetamol (PA) in 0.2 M phosphate buffer solution (PBS) at pH 7. The effect of concentration, scan rate, pH and surfactant was studied for electrochemical studies of paracetamol. The Diacerein modified carbon paste electrode showed an excellent electrocatalytic activity for the selective determination of PA in the presence of Dopamine and Diclofenac by using CV and differential pulse voltammetric techniques (DPV) respectively. The catalytic peak current obtained was linearly related to PA concentrations in the ranges of to 0.1 mM to 0.6 mM with correlation co-efficient of 0.9981 which reveals the adsorption controlled process. The detection limit of paracetamol was found to be 3.8×10−6 M. The present technique provides a novel method for the simultaneous determination of Paracetamol, Dopamine and Diclofenac in their mixture sample.