Title of article
Effects of Different Doses of Hyaloronan on Human Sperm Motility, Vitality and Morphology
Author/Authors
Mohammadi Roushandeh, Amaneh Department of Anatomy - School of Medicine - Tabriz University of Medical Sciences , Sohrabvand, Farnaz VALI-e-ASR Reproductive Health Research Center - Tehran University of Medical Sciences , Amanpour, Saeid VALI-e-ASR Reproductive Health Research Center - Tehran University of Medical Sciences , Pasbakhsh, Parichehr Department of Anatomy - Faculty of Medicine - Tehran University of Medical Sciences , Sobhani, Abdollah Department of Animal Sciences - Faculty of Agriculture - University of Mohghegh Ardabili, Ardabil , Nikzad, Hossein Department of Anatomy - Faculty of Medicine - Kashan University of Medical Sciences , Sobhani, Aligholi Department of Anatomy and VALI-e-ASR Reproductive Health Research Center - Faculty of Medicine -Tehran University of Medical Sciences
Pages
4
From page
369
To page
372
Abstract
Important aspect of sperm function such as motility and capacitation appear to be mediated at
least partially though hyaloronic acid (HA). Present study investigated effects of different doses of HA on
sperm motility and vitality in human. Sperm was obtained from 20 male from IVF clinic in Imam Khomeini
Hospital. Sperm motility and vitality in human semen was analyzed according to WHO criteria before and 4
hours after treatment with different doses of HA (0.750, 1000 and 1250 μg/ml). The results showed that in
1000 μg/ml the percent of stage 3 and 4 increased compare to control group. Percent of stage 1 and 2 decreased
in group with 1000 μg/ml HA, there was an increase in the percentage of stage 3 and 4 and decrease
in percentage of stage 1 and 2 compare to control. In the group treated with 1250 μg/ml stage 1 and 2 increased
while stage 3 and 4 decreased. Vitality in all groups decreased except of the group treated with 1000
μg/ml HA. The group with 1250 μg/ml showed significantly decrease in vitality compare to fresh group (P <
0.05). The present study showed that the effects of HA on sperm motility and vitality is dose dependant and
1000 μg/ml HA had the effective role on sperm parameters.
Keywords
Human sperm , hyaloronan , sperm parameters
Journal title
Astroparticle Physics
Serial Year
2009
Record number
2449140
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