Title of article
Pseudo-Five-Component Condensation for the Diversity-Oriented Synthesis of Novel Indoles and Quinolines Containing pseudo-Peptides (Tricarboxamides)
Author/Authors
Shiri, Morteza Department of Chemistry - Faculty of Science - Alzahra University - Tehran, I.R. IRAN , Momahed Heravi, Majid Department of Chemistry - Faculty of Science - Alzahra University - Tehran, I.R. IRAN , Zadsirjan, Vahideh Department of Chemistry - Faculty of Science - Alzahra University - Tehran, I.R. IRAN , Najatinezhad Arani, Atefeh Department of Chemistry - Faculty of Science - Alzahra University - Tehran, I.R. IRAN , Shintre, Suhas Ashok School of Chemistry and Physics - University of KwaZulu-Natal - Private Bag X54001 - Durban - 4000, SOUTH AFRICA , Koorbanally, Neil Anthony School of Chemistry and Physics - University of KwaZulu-Natal - Private Bag X54001 - Durban - 4000, SOUTH AFRICA
Pages
16
From page
101
To page
116
Abstract
A novel series of indole and quinoline tricarboxamides were synthesized using simple and efficient one-pot pseudo-five-component reactions of 2-formylindole or 2-chloro-3-formyl quinolines, isocyanides, amines, and Meldrum’s acid as a CH-acid in CH2Cl2 at room temperature. This conversion has been achieved via the construction of new bonds including two C-C bonds, two C-N bonds, and one C=O bond. Remarkably, three peptide bonds were formed through a domino sequence including Knoevenagel reaction, [1+4] cycloaddition, deacetonation and also, aminolysis reaction. Particularly, a number of structurally remarkable and pharmacologically significant products were provided in excellent yields.
Keywords
Multicomponent reaction , Tricarboxamide , Meldrum’s acid , Isocyanides , 2-chloro-3-formyl quinolone , 2-formylindole
Journal title
Astroparticle Physics
Serial Year
2018
Record number
2449272
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