Title of article
Endothelium-Dependent Attenuating Effect of Trigonella foenumgraecum on the Contractile Vascular Reactivity of Diabetic Rats
Author/Authors
Vaez Mahdavi, Mohammad Reza School of Medicine - Shahed University , Roghani, Mehrdad School of Medicine - Shahed University , Baluchnejadmojarad, Tourandokht School of Medicine - Iran University of Medical Sciences , Roghani Dehkordi, Farshad School of Medicine - Shahrekord University of Medical Sciences
Pages
5
From page
129
To page
133
Abstract
The present study was undertaken to determine whether two-month treatment of streptozotocin
(STZ)-diabetic rats with aqueous leaf extract of Trigonella foenum-graecum (TFG; 200 mg/kg; i.p.)
could improve thoracic aortic responsiveness and to evaluate its endothelium dependency. For this
purpose, vascular responses to KCl and noradrenaline (NA) were measured. Diabetic state
significantly increased contractile responses to KCl and NA in aortic rings in both endothelium-intact
and -denuded rings. Extract-treated diabetic rats showed a significant lower maximal contractile
response to KCl only in endothelium-intact rings as compared to diabetic rings. It is concluded that
intraperitoneal administration of aqueous leaf extract of TFG for two months could improve some
functional indices of the vascular system in diabetic state and the integrity of the endothelium is
essential for its beneficial effects
Keywords
Trigonella foenum-graecum (TFG) , Diabetes mellitus , Streptozotocin , aorta
Journal title
Astroparticle Physics
Serial Year
2005
Record number
2473569
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