Title of article
Anticonvulsant Effect of Ferula Gummosa Root Extract against Experimental Seizures
Author/Authors
Sayyah, Mohammad Dept. of Physiology and Pharmacology - the Institute Pasteur of Iran , Mandgary, Ali Dept. of Physiology and Pharmacology - the Institute Pasteur of Iran
Pages
5
From page
139
To page
143
Abstract
In Iranian traditional medicine, there are some report regarding the anticonvulsant effect of Ferula gummosa Boiss. In this study, anticonvulsant activity, neurological deficits and lethality of the root acetone extract of this plant were evaluated in mice. The extract exhibited dose-dependent prevention of tonic seizures induced by pentylenetetrazole (ED50 = 154.4 mg/kg). However, the extract produced sedation and motor impairment with TD50 value of 546 mg/kg. Preliminary phytochemical analysis showed the presence of terpenoids, alkaloids and a little amount of cardenolids in the extract. It seems that the anticonvulsant and neurotoxic effects of the extract is related in part to the terpenoid compounds. The acceptable protective index of the extract (3.5) recommends further studies on Ferula gummosa
Keywords
Ferula gummosa , Anticonvulsant activity , Root , Acetone extract
Journal title
Astroparticle Physics
Serial Year
2003
Record number
2473888
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