Title of article
Evaluation of Humoral Immune Function in Patients with Chronic Idiopathic Thrombocytopenic Purpura
Author/Authors
Rahiminejad, Mohammad Saeid Department of Pediatrics - Pediatrics Center of Excellence - Children's Medical Center - Tehran University of Medical Sciences , Mirmohammad Sadeghi, Mehrdad Department of Pediatrics - Pediatrics Center of Excellence - Children's Medical Center - Tehran University of Medical Sciences , Mohammadinejad, Payam Research Center for Immunodeficiencies - Tehran University of Medical Science , Sadeghi, Bamdad Research Center for Immunodeficiencies - Tehran University of Medical Sciences, Tehran , Abolhassani, Hassan Research Center for Immunodeficiencies - Tehran University of Medical Sciences, Tehran , Dehghani Firoozabadi, Mohammad Mehdi Research Center for Immunodeficiencies - Tehran University of Medical Sciences, Tehran , Fathi, Seyed Mohammad Department of Pediatrics - Pediatrics Center of Excellence - Children's Medical Center - Tehran University of Medical Sciences , Rezvani, Hamid Department of Pediatrics - Taleghani Hospital - Shahid Beheshti University of Medical Sciences, Tehran , Bahoush, Gholamreza Department of Pediatrics - Aliasghar Children's Hospital - Tehran University of Medical Sciences, Tehran , Ehsani, Mohammad Ali Department of Pediatrics - Bahrami Children's Hospital - Tehran University of Medical Sciences, Tehran , Faranoush, Mohammad Department of Pediatrics - MAHAK Children's Hospital - Shahid Beheshti University of Medical Sciences, Tehran , Mehrvar, Azim Department of Pediatrics - MAHAK Children's Hospital - Shahid Beheshti University of Medical Sciences , Torabi Sagvand, Babak Research Center for Immunodeficiencies - Tehran University of Medical Sciences, Tehran , Ghadiani, Mojtaba Department of Pediatrics - Taleghani Hospital - Shahid Beheshti University of Medical Sciences , Rezaei, Nima Department of Pediatrics - Pediatrics Center of Excellence - Children's Medical Center - Tehran University of Medical Sciences, Tehran , Aghamohammadi, Asghar Department of Pediatrics - Pediatrics Center of Excellence - Children's Medical Center - Tehran University of Medical Sciences
Pages
7
From page
50
To page
56
Abstract
Coincidence of autoimmune diseases such as immune thrombocytopenic purpura (ITP)
with immunodeficiencies has been reported previously in patients who suffered from
primary antibody deficiency (PAD). But there is no original study on immunological profiles
of ITP patients to find out their probable immune deficiency.
In this case-control study, ITP patients’ humoral immunity was investigated for diagnosis
of PAD in comparison with normal population. To evaluate the humoral immune system
against polysaccharide antigens, patients’ serum immunoglobulin levels were measured and a
23-valent pneumococcal capsular polysaccharide vaccine (PPV23) was administrated to
evaluate the antibody response to vaccination.
In this study, 14 out of 36 patients (39%) were diagnosed with antibody mediated
immune deficiency including 2 patients (5.5%) with immunoglobulin class deficiency and 4
(11%) with IgG subclass deficiency. The remaining patients suffered from specific antibody
deficiency. The most frequent deficiency in ITP patients was specific antibody deficiency.
Therefore, immunological survey on ITP patients may be important especially for those
who have undergone splenectomy.
Keywords
Idiopathic , Immunologic Deficiency Syndromes , Purpura , Splenectomy , Thrombocytopenic
Journal title
Astroparticle Physics
Serial Year
2013
Record number
2476983
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