Synthesis of silver-cobalt nanoparticles by chemical reduction method and its effects on serum levels of thyroid hormones in adult male rats

Objective(s): Silver-cobalt nanoparticles have anti-fungal properties and are used in medicine. In this research, the effect of silver-cobalt nanoparticles on serum levels of T3 and T4 hormones was investigated. Silver-cobalt nanoparticles were synthesized by chemical reduction. Methods: In this experimental study, 28 male adult Wistar rats (approximately 180-220 gr) were used. Animals were divided into 4 groups of 7. The control group were not affected by any treatment. Experimental groups 1 and 2 received 25 and 100 mg / kg of silver-cobalt nanoparticles, in which silver nanoparticles were synthesized during 75 seconds intraperitoneally for 14 days, respectively. The experimental group 3 received 25 mg / kg of silver-cobalt nanoparticles, in which silver nanoparticles were synthesized during 300 seconds intraperitoneally for 14 days. At the end of the trial, blood sampling was performed to measure hormones. The mean serum levels of T3 and T4 hormones were analyzed by appropriate statistical tests including ANOVA and Duncan test. Results: Serum levels of T4 in experimental groups 2 and 3 showed a significant decrease compared to control group. Serum T3 level did not change significantly in all experimental groups compared to control group (p 0.05). Conclusions: Silver-cobalt nanoparticles reduced the serum T4 level.