Title of article
Effects of Buthus eupeus Venom on Neuromuscular Transmission on Striated Muscle In Vitro
Author/Authors
Vatanpour, Hossein Department of Pharmacology and Toxicology - School of Pharmacy - Shahid Beheshti University , Nasoohi, Sanaz Department of Pharmacology and Toxicology - School of Pharmacy - Jundishapur University of Medical science , Jalali, Amir Department of Pharmacology and Toxicology - School of Pharmacy - Jundishapur University of Medical science
Pages
4
From page
121
To page
124
Abstract
In this study, effects of Buthus eupeus venom on chick biventer cervices nerve-muscle preparation were investigated by twitch tension method. The venom, at 1.3 ?g/ml, increased contractile responses in indirect stimulations. These effects were milder in direct muscle stimulations. It also caused significant enhancement in postjunctional sensitivity as assessed by responses to exogenous acetylcholine, carbacole and potassium chloride. These results indicate that B. eupeus venom can cause irreversible facilitation of neuromuscular transmission by affecting postjunctional excitability in both nicotinic receptors and ion channels of the muscle cells membrane.
Keywords
Buthus eupeus , Neuromuscular transmission , Skeletal muscle , Venom
Journal title
Astroparticle Physics
Serial Year
2009
Record number
2483104
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