Title of article
Colchicine Overdose in a Suicidal Attempt
Author/Authors
Eghbali ، Fatemeh Student Research Committee, School of Pharmacy - Shahid Sadoughi University of Medical Sciences , Bidaki ، Reza Department of Psychiatry - School of Medicine, Research Center of Addiction and Behavioral Sciences, Diabetes Research Center - Shahid Sadoughi University of Medical Sciences and Health Services , Negintaji ، Sina Student Research Committee, School of Pharmacy - Shahid Sadoughi University of Medical Sciences , Dehghani ، Maryam Student Research Committee, School of Pharmacy - Shahid Sadoughi University of Medical Sciences , Sahebnasagh ، Adeleh Department of Internal Medicine - School of Medicine, Imam Ali Hospital - North Khorasan University of Medical Sciences , Bagheri Atabak ، Ali Asghar Department of Medical Student - School of Medicine - Shahid Sadoughi University of Medical Sciences and Health Services , Saghafi ، Fatemeh Department of Clinical Pharmacy, Faculty of Pharmacy and Pharmaceutical Sciences Research Center - Shahid Sadoughi University of Medical Sciences
Pages
6
From page
265
To page
270
Abstract
Colchicine overdose is uncommon; however, it can cause serious adverse effects and even death. Colchicine inhibits microtubule polymerization, causing mitotic spindle disruption. Ingesting ˃0.5 mg of colchicine per kilogram bodyweight causes severe adverse effects and can even be fatal. Therefore, colchicine toxicity must be accurately monitored and managed.In this case report, we described a 21yearold woman who attempted suicide by the ingestion of an estimated 30 mg colchicine. She was admitted to the hospital due to severe abdominal and chest pain, vomiting, lethargy, and weakness. The patient was medicated with ondansetron, apotel, antibiotics, platelet transfusions, sodium phosphate, calcium gluconate, calcitriol, desmopressin acetate, GranulocyteColony Stimulating Factor (GCSF), and sodium bicarbonate. Fortunately, through the appropriate medical treatment, the signs and symptoms of colchicine toxicity were relieved and the patient survived despite the high colchicine serum level.
Keywords
Colchicine , toxicity , Case
Journal title
International Journal of Medical Toxicology and Forensic Medicine
Serial Year
2019
Journal title
International Journal of Medical Toxicology and Forensic Medicine
Record number
2484060
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