Title of article
The Emerging Role of Succinate Dehyrogenase Genes (SDHx) in Tumorigenesis
Author/Authors
Nazar, Elham Department of Pathology - Shariati Hospital - Tehran University of Medical Sciences, Tehran , Khatami, Fatemeh Tehran University of Medical Sciences, Tehran , Saffar, Hiva Department of Pathology - Shariati Hospital - Tehran University of Medical Sciences, Tehran , Tavangar, Mohammad Department of Pathology - Shariati Hospital - Tehran University of Medical Sciences, Tehran
Pages
11
From page
72
To page
82
Abstract
Transformation of a normal cell to cancerous one is dependent on the accumulation of several genetic and epigenetic alterations. One of the candidate driver genetic alterations can happen in succinate dehydrogenases (SDHx) coding gene include SDHA, SDHB, SDHC, SDHD, and SDHAF2. The most important SDH mutation is in the SDHD gene, which encodes the smallest subunit of mitochondrial complex II (SDH). It has key function both in familial and non-familial hereditary paraganglioma/phaeochromocytoma syndrome (HPGL/PCC). SDHx genes mutations can have resulted in genetic and epigenetic changes like histone hypermethylation. These properties can lead to succinate-mediated inhibition of α-ketoglutarate-dependent dioxygenases. So hypoxic conditions can generate subsequent neoplastic transformation, and in this review, we are presenting the role of SDHx in several malignancies.
Keywords
Succinate dehydrogenases , Tumor , Genetic
Journal title
Astroparticle Physics
Serial Year
2019
Record number
2484890
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