Title of article
T Regulatory Cells Frequency During Maintenance Phase Chemotherapy for Pediatric Acute Lymphoblastic Leukemia
Author/Authors
Garcia-Hernandez, Mariana Haydee Unidad de Investigación Biomédica de Zacatecas - Delegación Zacatecas - Instituto Mexicano del Seguro Social - IMSS , Medina-Rosales, Marina Nayeli Unidad de Investigación Biomédica de Zacatecas - Delegación Zacatecas - Instituto Mexicano del Seguro Social - IMSS , Godina-Gonzalez, Susana Facultad de Ciencias Qumicas - Universidad Autónoma de Zacatecas - UAZ, México
Pages
7
From page
87
To page
93
Abstract
Drugs used in cancer treatment specifically kill T regulatory cells. Objective: To determine different phenotypes of T regulatory cells during the maintenance phase chemotherapy for pediatric acute lymphoblastic leukemia (ALL). Materials: We evaluated the percentages of regulatory T cells by flow cytometry. Soluble CTLA-4 (sCTLA-4) in plasma was evaluated by ELISA assay. Results: Increased percentages of CD4+CD25+ T cells, CD4+CD39+ T cells, CD4+Foxp3+ T cells, and CD4+CD25High T cells were observed in children with ALL in comparison to healthy controls. In addition, the ALL patients with >12 months of therapy showed increased CD4+CD39+ T cells compared to the ALL patients with ≤12 months and healthy controls. Similarly, the CD4+CD25+ T cells and CD4+Foxp3+ T cells increased according to maintenance therapy time. Conclusion: Our results showed increased percentages of regulatory T cells in pediatric ALL patients despite chemotherapy, which might be compromising the anti-leukemic cellular immune response.
Keywords
T Regulatory Cells , Chemoterapy, Pedriatic , Acute Lymphoblastic Leukemia , ALL
Journal title
Astroparticle Physics
Serial Year
2020
Record number
2487435
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