Modifying “Pico” Question into “Picos” Model for More Robust and Reproducible Presentation of the Methodology Employed in A Scientific Study

The mnemonic “PICO” was originally coined to help guide a standardized and disciplined way of formulating a clinical research question, carrying out a thorough literature search to answer that question (particularly through the MEDLINE/PubMed) and resultantly generate a fulfilling and all encompassing evidencebased answer to the constructed clinical query. The elements of the PICO question included “P” for problem or patient or population, “I” for intervention or exposure, “C” for comparison and “O” for outcomes. The PICO question was recommended to be phrased into appropriate search strings to find out all the relevant published quality literature available on the cyberspace.