The effect of oleuropein on working and passive avoidance memory in the pentylenetetrazole-induced seizure animal model

Introduction: Epileptic seizures are product of abnormal electrical discharges of the brain. Electrical wave productive of epileptic seizure generates disturbances in brain data processing circuits and these patients suffer from memory impairment. In this study, the effect of different doses of oleuropein on the treatment of memory impairment Caused by frequent seizures was in male rats investigated. Materials and methods: Forty rats were randomly divided into four groups of 10 (the negative control group received normal saline, the positive control group received diazepam 1 mg/kg and the two treatment groups received doses 10 and 20 mg/kg of oleuropein). Thirty minutes after administration of different doses of oleuropein or saline or diazepam, pentylenetetrazole (PTZ) at a dose of 85 mg/kg was injected intraperitoneal into rats, and after creating seizure and animal survival, tests of memory were performed. One-way ANOVA and Tukey's tests were the procedures used to analyze the results. Results: In both tests, the memory of the control group (normal saline recipient) decreased significantly (P<0.001). The administration of 10mg/kg oleuropein shows a significant increase in periodic behavior measurements by maze y (P<0.01). Both doses of 10 and 20 mg/kg increased passive avoidance memory (P<0.001). Conclusion This study shows that the oleuropein has an appropriate anticonvulsant effect and improves the working memory and passive avoidance in epileptic rat and Future studies appear to be necessary to understand further how the mechanism of its effect.