The Effect of Vitamin E and Vitamin C on Quality of Life in Patients with Type 2 Diabetes: A Single-Blind Randomized Clinical Trial

background: diabetes mellitus as one of the prevalent endocrine disease is associated with a high burden of oxidative stress due to the overproduction of reactive oxygen species (ros), which may lead to decreased antioxidant defense system, increased risk of inflammation, neuropathy, nephropathy, and cardiovascular disease. all of these may, in turn, cause a reduced quality of life in these patients. objectives: this study aimed to evaluate the effect of vitamin e and vitamin c on the quality of life in patients with type 2 diabetes. methods: forty-five patients with type 2 diabetes were randomly divided into three groups to receive vitamin e (400 iu day-1), vitamin c (1000 mg day-1), and placebo for six weeks. before and after the intervention, the quality of life was assessed with a valid persian version of sf-36 (short-form health survey-36) questionnaire. results: supplementation with vitamin e and vitamin c were associated with significant improvements in the role limitations due to physical health (p = 0.02) and general health (p = 0.05). furthermore, there were significant increases in the role limitations due to physical health, role limitations due to emotional problems, social functioning, and general health in the vitamin e group. also, a significant increase was observed in general health score in the vitamin c group. conclusions: this study indicates that short-term supplementation of vitamin e and vitamin c may improve the quality of life in patients with type 2 diabetes through alleviating oxidative stress.