The effects of IL-8, IL- 6 and IL-1 on the risk of celiac disease: a bayesian regression analysis

Abstract Aim: The present study aimed to evaluate the association between serum levels of interleukin IL-1, IL-6, IL-8 genes as well as interferon (IFN)-? and the risk of celiac disease (CD). Background: The role of serum cytokine levels in the pathophysiology of CD is still an open field to be explored. Methods: This case-control study was performed on 110 patients with CD and 46 healthy controls referring to Taleghani Hospital, Tehran, Iran. Expression levels of IL-1, IL-6, IL-8, and IFN-? were assessed by enzyme-linked immunosorbent assay (ELISA) kits. Results: The Bayesian intervention odds ratio (OR) and Highest Posterior Density (HPD) interval were 1.133 (95% credible interval 1.018- 1.269), 0.947 (95% credible interval 0.898 - 0.996) and 1.004 (95% credible interval 1.001- 1.009) for IL-1, IL-6, and IL-8 respectively. Conclusion: The serum level of IFN-? has no effect on the risk of CD, but given the o‎r and the HPD interval obtained for serum levels of IL-1, IL-6 and IL-8, with one unit increase in IL-1 serum, the risk of CD grows by 1.13 times while one unit increase in IL-6 serum reduces the risk of CD by 15%. Finally, regarding IL-8, the risk of CD increases by 0.004 times with a unit increase in IL-8 serum. Keywords: Celiac disease, Cytokines, Bayesian logistic regression model. (Please cite as: Nasserinejad M, Shojaee S, Ghobakhlou M, Lak E, Eslami P, Pourhoseingholi MA. The effects of IL-8, IL- 6 and IL-1 on the risk of celiac disease: a Bayesian regression analysis Gastroenterol Hepatol Bed Bench 2019;12(Suppl.1):S117-S122).