Title of article
A deductive kinetic study of diclofenac release from chitosan-based magnetic nanocomposite hydrogels
Author/Authors
Zargazi, M. H. Department of Chemistry - Islamic Azad University, Karaj , Ghadimi Yari, M. Department of Chemistry - Islamic Azad University, Karaj , Kurdtabar, Mehran Department of Chemistry - Islamic Azad University, Karaj
Pages
11
From page
37
To page
47
Abstract
A descriptive study of isothermal kinetics of diclofenac release from chitosan-g-acrylic acid (Chit-AA) hydrogel and chitosan-g-(acrylic acid-co-[2-(acryloyloxy)ethyl]trimethylammonium chloride) (Chit-AA-AETM) hydrogel was carried out. Isothermal kinetic curves for diclofenac release from both hydrogels in distilled water at various temperatures of 20-42°C were studied. The fit method of the famous model was used to determine the kinetic models of both the drug release process and the external solvent absorption onto the hydrogel. Based on the fixed dependencies of kinetic parameters (LnA, Ea) on the amount of abandoned diclofenac (α) in the presence of compensatory effect, the function of the new molecular mechanism of a drug transfer process was investigated. According to that mechanism, drug release is considered as an isolation of the drug from the active separation centers of various hydrogels with different energies.
Keywords
drug delivery systems , isothermal kinetics , hydrogel , drug release
Journal title
Journal of Physical and Theoretical Chemistry
Serial Year
2019
Record number
2501469
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