Repairing Injured Skin: Biologics, Skin Substitutes, and Scaffolds: Review

Context: Skin damage is one of the most common injuries that occur daily for millions around the world. Considering this high prevalence, developing new methods of cells and stem cell administration for healing injured skin is necessary.We discuss different new methods of stem cell and cell administration for repairing injured skin, such as skin stem cell gun, scaffolds, hydrogels, and autologous keratinocytes sheets. Evidence Acquisition: Many approaches are available in injured skin healing, such as traditional therapy, transplanting, cell therapy, and stem cell therapy. Skin grafting is still a standard solution to treat patients; however, there are a lot of limitations in this procedure, for example, patients with severe burns have an insufficient skin area for grafting, which is a painful procedure. Results: Although cell therapy approaches dissolve scarring and reduce healing time, considering its high cost, they are not used in everyday society. This article discusses different regenerative dermatology products and compares them with each other. Conclusions: Herein, we introduced several examples of skin cell products in the pharmaceutics market. Although these products are not wellknownandevensomeof themdidn’t reach clinical trials, comparing different kinds of skin engineered products reveals appropriate guidelines for their use and entrance to dermatology market.