Title of article
Synthesis and Biological Evaluation of 2-Phenyl Benzothiazole Derivatives as Cytotoxic Agents
Author/Authors
L. Firoozpour Drug Design and Development Research Center - Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran , Moghimi, S. Drug Design and Development Research Center - Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran , Safavi, M. Department of Biotechnology - Iranian Research Organization for Science and Technology, Tehran, Islamic Republic of Iran , Foroumadi, A. Department of Medicinal Chemistry - Faculty of Pharmacy and Pharmaceutical Sciences Research Center - Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran
Pages
6
From page
335
To page
340
Abstract
Cancer is a leading cause of death worldwide. Many heterocyclic cores are present in the structures of clinically approved anticancer drugs. Meanwhile, benzothiazoles have been reported as one of the most important heterocyclic scaffolds in previously reported anticancer agents in the literature. Therefore, in this report, a novel series of 2-phenyl benzothiazole derivatives was synthesized, biologically evaluated against breast cancer cell line (T47D) and compared with etoposide as a reference drug. The anticancer activities were evaluated by MTT colorimetric assay. Among all tested compounds, N-(4-(6-methoxybenzo[d]thiazol-2-yl)phenyl)acetamide illustrated the most potent cytotoxic activity.
Keywords
Phenyl benzothiazole , Thiobenzanilides , Jacobson synthesis , cancer
Journal title
Journal of Sciences
Serial Year
2018
Record number
2509431
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