Title of article
Rate accelerations in trichloroisocyanuric acid and trichlorotriazine promoted synthesis of 3,4-dihydropyrimidinones/thiones under Vilsmeier-Haack and solvent free conditions
Author/Authors
Duguta ، Govardhan Department of Chemistry - Osmania University , Mukka ، Satish Kumar Department of Chemistry - Osmania University , Yelike ، Hemanth Sriram Department of Chemistry - Osmania University , Kamatala ، Chinna Rajanna Department of Chemistry - Osmania University , Mukka ، Sai Sudhakar Department of Chemistry - BITS Pilani, Hyderabad Campus
From page
457
To page
472
Abstract
In the present study, we have accomplished N,N’-dimethyl formamide (DMF)/trichloroisocyanuric acid and DMF/trichlorotriazine as efficient catalysts for the synthesis of 3,4-dihydropyrimidinones/thiones from one-pot multi-component reaction of β-ketoester, aromatic aldehydes, and urea under reflux condition. The reaction operates also under solvent free microwave condition. The results obtained from this study were compared with those obtained from classical Vilsmeier-Haack adducts (DMF/POCl3 and DMF/SOCl2) as catalysts. Reaction times and product yields observed in this study indicated shorter reaction times and better product yields with modified VH reagents (TCCA/DMF and TCTA/DMF) over classical VH reagents (POCl3/DMF and SOCl2/DMF). The catalytic activity of (TCTA/DMF) (TCCA/DMF) (POCl3/DMF SOCl2/DMF).
Keywords
DMF , trichloroisocyanuric acid , DMF , trichlorotriazine , Green Vilsmeier , Haack reagents Rate , enhancements , Microwave assisted reactions
Journal title
Asian Journal of Green Chemistry
Journal title
Asian Journal of Green Chemistry
Record number
2509748
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