Introducing Self-Nanoemulsifying Drug Delivery System to Increase the Bioavailability of Oral Medications

The oral route is the most convenient route of administration of drugs because of low cost, ease of administration, patient compliance and flexibility in design of dosage form. Regardless of the advantages of this method, the main challenge in the bioavailability of oral drugs is gastrointestinal instability. Nanotechnology is used to improve the solubility and bioavailability of poorly water-soluble drugs. The self-nanoemulsifying drug delivery system is an ideal method for improving the solubility and bioavailability of poorly water-soluble drugs. This system is stable mixture of oil, surfactant and cosurfactant. The combination of these components creates an oil-in-water nanoemulsion, with droplet in the nanometer size range and ultimately increases the bioavailability and oral absorption of poorly water-soluble drugs. This system not only increases the medication s effectiveness, but it also reduces undesirable side effects.