A Simple, Solvent-free Four-component Domino Synthesis of 1H-pyrazolo [1, 2-b] phthalazine-5, 10-dione Derivatives Catalyzed by Copper (II) oxide

An eco-safe and facile multi-component domino reaction has been described for the synthesis of 1H-pyrazolo [1, 2-b] phthalazine-5, 10-dione derivatives. The products were obtained by a fourcomponent condensation reaction between phthalimide, hydrazine monohydrate, aromatic aldehyde derivatives and malononitrile in the presence of a catalytic amount of copper (II) oxide (CuO) under solvent-free conditions in high yields. The advantages of this one-pot procedure is environmentally friendly, efficient and economic availability of the catalyst, short reaction times, solvent-free conditions and clean reaction profiles.