Comparison of serum levels of calcium, vitamin-D, phosphorous and C-reactive protein in acne patients versus healthy subjects

Background: Acne vulgaris is among common bothersome skin problems. Recognition of contributing factors would help to prevent acne. Some dietary and inflammatory factors are among suggested etiologies. Accordingly, in this study, the serum levels of calcium, vitamin D, phosphorous and C-reactive protein (CRP) were determined and compared in acne patients and healthy subjects. Methods: In this case-control study, 144 consecutive subjects with and without acne (moderate-very severe) referred to Rasoul Akram Hospital in 2016 were enrolled. In this regard, the serum calcium, phosphorous, CRP, vitamin D were determined in the subjects and compared between the groups. Results: The results indicated that serum CRP, calcium, and phosphorous level were alike between the groups (P > 0.05) without any relation to acne severity except CRP. The serum vitamin D level was significantly different (P = 0.0001), but it was not associated with acne severity. Serum calcium levels of males were significantly higher in both groups. Conclusions: Based on our results, it may be concluded that calcium, phosphorous, and CRP levels are not associated with acne incidence, but the serum vitamin D is related to acne presentation. CRP levels were positively associated with acne vulgaris severity.